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ScienceDaily (Mar. 30, 2009) — For some people it is a certainty: as soon as the annual flu season gets underway, they are sure to go down with it. It is little comfort to know that there are other people who are apparently resistant to flu or overcome the illness after just a couple of days. It is this phenomenon that is now being investigated by researchers at the Helmholtz Center for Infection Research, using various strains of mice.

“Where there are many scientific works dealing solely with the flu virus, we have investigated how the host reacts to an infection,” says Klaus Schughart, head of the Experimental Mouse Genetics research group. In infection experiments the researchers have now discovered that an excessive immune response is responsible for the fatal outcome of the disease in mice. This overreaction has genetic roots.

For their investigations the researchers injected seven different inbred mouse strains with the same quantity of type Influenza A flu viruses. All of the animals within one mouse strain are genetically identical, like identical twins. However, one strain differs from another just like different individuals in the human population. To their surprise, the researchers were able to identify strong differences in the progression of the influenza between the seven strains. In five of the strains the illness was mild: the animals lost weight, recovering completely after seven to eight days. However, in two of the mouse strains the animals lost weight rapidly and died after just a few days.

The researchers looked for reasons for these differences: they investigated how the immune system of the animals responds to the virus. “The mice die from their own immune defences, which are actually supposed to protect them against the virus. The immune system produces too many messengers, which have a strong activating effect on the immune cells. These cells then kill tissue cells in the lungs that are infected with the virus,” says Schughart. At the same time, these overactive cells also destroy healthy lung tissue. In mice that died the researchers also found one hundred times more viruses than in animals that survived. “It appears that the animals have specific receptors on their cells that make them more receptive to a severe viral infection.” Flu infections in humans could take a similar course, here too, genetic factors could favour a severe progression of the illness. “It is only now that we are beginning to understand the role played by the genetic factors of the host and what increased receptiveness means in the case of influenza,” says Schughart.

Every year between 10,000 and 30,000 people in Germany die from influenza, the majority via pathogens of the Influenza A type. There are various sub-types of the main type A, in which the composition of the virus envelope differs. H1N1 and H3N2 are the most widely-distributed flu strains amongst humans, H5N1 the familiar avian flu virus. The H stands for the protein haemagglutinin, with which the virus latches onto the cells of the airways, infecting them. In order for the newly-created flu viruses to leave the host cells, in turn, they require neuraminidase (N). To evade an immune response the virus changes the H and N characteristics constantly. Sometimes light, sometimes heavy: the result is a completely new virus type with a new number, with the consequences generally a severe global flu pandemic.

Journal reference:

1. Srivastava et al. Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections. PLoS ONE, 2009; 4 (3): e4857 DOI: 10.1371/journal.pone.0004857

Adapted from materials provided by Helmholtz Association of German Research Centres, via EurekAlert!, a service of AAAS.

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By Anju Shandilya
Published: 1/2/2008

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By Reshma Jirage
Published: 2/9/2009

Popularity: 75% [?]

ScienceDaily — Findings just published in the journal Immunity by researchers at the Trudeau Institute shed new light on how a previously-unknown messaging mechanism within the human immune system prompts specific influenza-fighting cells to the lung airways during an infection.

Infections from the influenza virus are responsible for hundreds of thousands of hospitalizations and as many as 40,000 deaths in the United States each year. Although researchers have known for some time that white blood cells congregating in the lung and directly attacking the virus play an important role in defending against influenza, it has never been clear how exactly these white blood cells know when they are required in the lung.

Now new research in the Trudeau Institute laboratory of Dr. David Woodland offers important insights into the navigational aids used by these cells as they maneuver through the human body. Trudeau investigators have shown that lungs which have been infected with the influenza virus produce a series of chemicals, or chemokines, which act as beacons for specific types of white blood cells. While circulating in the bloodstream, these white blood cells recognize the chemical messages signaling the presence of the virus and the need for them to move into lung tissues.

According to Dr. Woodland, director of the Trudeau Institute and lead researcher on the project: “An important aspect of these findings is that this response occurs early in the disease process, typically within a couple of days of the initial infection. It also turns out that only a fraction of the available white blood cells are capable of recognizing these chemokine messages. Discovering that this response occurs rapidly, and that only a specific subset of white blood cells can recognize these messages, helps provide important new information for researchers working towards developing better a better influenza vaccine.”

The Trudeau Institute is an independent, not-for-profit biomedical research organization with a scientific mission to make breakthrough discoveries leading to improved human health. Trudeau researchers are identifying the basic mechanisms used by the immune system to combat cancer and infectious diseases, such as influenza and tuberculosis, so that better vaccines and therapies can be developed. The research is supported by government grants and philanthropic contributions.

Journal reference:

1. . The Chemokine Receptor CCR5 Plays a Key Role in the Early Memory CD8? T Cell Response to Respiratory Virus Infections. Immunity, July 2008

Adapted from materials provided by Trudeau Institute.

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Healing Herbs for Preventing and Curing Cancer

Dina Hunter

Healing Herbs for Preventing and Curing Cancer No one knows exactly what causes cancer. Research has learned that when the immune system slows down or cannot work properly, cancer and other immune failure diseases seem to take over. The white blood cells are a main part of the immune system. When the white blood cells die or in some way become impaired, the immune system breaks down. Conventional cancer treatments usually consist of surgery, chemotherapy and radiation therapy. These can all lower your white blood cell count and wreak havoc with your immune system. White blood cells are very tough little guys, swimming through our veins, attacking infections and various other “bad germs” in our blood. But they are vulnerable to certain things. They can not do their job well when there is infection. They are killed off by chemotherapy, radiation, mold, chlorine and fluoride in our water supply and metal toxins such as mercury, iron or aluminum. What’s even more frightening is antibiotics, as well as, some pharmaceutical drugs that we are given to help combat disease and infection can sometimes destroy the white blood cells. Many times the very drugs and treatments that kill cancer end up killing the patient because their organs break down and fail to function. So there goes our immune system. In 2002 I was diagnosed with breast cancer. I endured surgery and chemotherapy, which made me horribly sick and left me so weak I could barely walk across the room. When I told the oncologist I was sick and vomiting for several days after each chemo session, she told me it couldn’t be the chemo making me sick. It had to be something else making me vomit. Even after the chemo sessions were over, I was still too weak to do much of anything. I asked the oncologist if there were any herbs or certain kinds of foods I should eat. She said, “No, just eat what you normally eat.” She obviously had no knowledge of herbs or nutrition. So, it looks to me like, if you’re suffering from the effects of chemotherapy or radiation, you’re pretty much on your own. It’s very hard to cope with these vague feelings of tiredness, no energy, depression, irritability, loss of appetite, memory loss and concentration. Most doctors seem to feel these symptoms are unimportant and dismiss them without much thought. One thing we can do is take advantage of the many cancer fighting, immune enhancing herbs, some of which have been around for 1000s of years. Scientists around the world are concentrating on herbal medicines to boost the immune cells of the body in it’s fight against cancer. Find a good herbalist or Doctor of alternative medicine. He or she can put together an herbal formulation based on your body, it’s needs and your life style. Because there are many kinds of cancer and different herbs work in different ways, they are usually not given singly. They work much better in synergistic combinations. Some herbs fight disease by enhancing the immune system. Others work with the lymph system to neutralize toxins and encourage drainage of fluids which flush toxins out of the body. Water, although not an herb, does a very good job of flushing toxins from the body. Just make sure the toxic chemicals that are added to most water systems are filtered out before you drink it. According to the Department of Agriculture there are over 3000 herbs that contain anti-cancer properties. Following is a list of the more common herbs for treating this dreaded disease. Astragalus has been used for more than 5000 years in China. It enhances the immune cells and the natural killer cells that are known to destroy cancer cells. It has been shown in research to speed recovery from chemotherapy and radiation treatments and prolong life expectancy. Astragalus is rarely given alone. According to Chinese medicine it works best when given along with other immune enhancing herbs. Some studies do show that it is effective when used alone and it is certainly worth using. Flaxseed supplements help balance the hormonal system and enhances the immune system and is recommended as a preventative for women who are concerned about breast cancer. Doctors in Germany have been using yarrow along with surgery, radiation and chemotherapy. Garlic and onion has been shown to reduce the risk of cancer of the colon, esophagus and the stomach. Hippocrates was the first to recommend it’s use. Antioxidants are found in most fruits, vegetables and herbs and are known to fight cancer and other diseases. Pau D Arco has been known to shrink cancerous tumors. Burdock, Cat’s Claw, sweet potatoes and pineapple, all have cancer fighting qualities which can detoxify your body and boost the immune system. If you don’t have an herbalist or doctor who will prescribe a synergistic herbal combination to fight cancer for you try eating a wide variety of herbs known to fight cancer and rejuvenate the immune system. Find more information about combating disease with herbs at www.healthyherbalplants.com .

Article Source: http://www.articlesbase.com/cancer-articles/healing-herbs-for-preventing-and-curing-cancer-482749.html

About the Author:

Dina Hunter is the author and owner of www.healthyherbalplants.com She is a firm believer in natural healing with fresh natural foods and herbs.She uses herbs for pain, stress and joint care As a cancer survivor she has done a lot of research on herbs to help This article discusses relevant herbs for preventing and curing cancer and helping the body cope with radiation and chemotherapy, recover from the effects of chemotherapy and radiation.

http://www.articlesbase.com/cancer-articles/healing-herbs-for-preventing-and-curing-cancer-482749.html

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The ability of the immune system to fight disease is dependent upon the level of general health and physical fitness. However, even a. healthy body will have its immunocompetence severely reduced by excessive stress or fatigue. The reason for this is that, amongst other things, stress increases the viscosity of the blood.

The blood is an all-important factor in the promotion of effective immune responses. A high blood viscosity brought about by stress, or lack of physical fitness, results in a breakdown of efficiency in the components of the immune system. When a person is physically unfit, overweight or stressed, the blood becomes clogged with cholesterol, triglycerides (fats), and various waste products. The fat causes the red cells to stick together with tiny particles called platelets, whose function is to clot the blood in the event of injury. As a result, the blood becomes sludgy and sticky and its oxygen carrying capacity is reduced. This factor, plus the narrowing of arteries by cholesterol deposits, means that it can no longer flow freely.

When these circumstances occur, the white cells and antibodies cannot function properly, resulting in impairment of the immune system. It is vital therefore, in the treatment of chronic allergy conditions, to achieve and maintain low blood viscosity. This can be done by shedding excess weight, regular exercise and the reduction of dietary cholesterol and fats.

The newborn baby does not have a fully functioning immune system or digestive system. These develop during the first twelve months of life. During this critical period, the child is dependent on the mother’’s milk to provide immunoglobulins for protection and enzymes for digestion. Breast milk contains substances which give the infant immunity, as well as nutrients and enzymes in the exact proportion necessary for the baby’’s needs. For this reason, a baby should be breast-fed for at least the first six months of life. If the child is introduced to foreign substances, such as cow’’s milk and cereals too early, permanent damage to the developing immune system and lifelong allergy problems can result.

During the first few months of life a child does not produce enough enzymes to break down introduced foods sufficiently. A baby’’s gut is very porous and relies on a secretion from the mother’’s breast, called colostrum, which acts as a coating, thus preventing harmful protein molecules passing through the gut wall into the blood.

If the child is denied this protection, undigested food particles will enter the bloodstream and confuse the developing immune system, which then accepts them as normal. This causes immunological havoc and instead of being digested by enzymes and white cells, the substances may be ignored by the immune system and left to cause allergy reactions. The problem may continue into adult life, causing further damage to the body and increasing illness.

Immunotherapy is one method of attempting to help or stimulate the immune system to overcome a disease condition. With respect to complex allergy problems, especially those concerning food and chemicals, this approach is rarely successful. Apart from the difficulty in obtaining accurate diagnosis, the process seeks to stimulate something which is often too overloaded to respond.

The most effective method of helping the immune system is by diet and exercise. Abstinence from allergenic foods, together with additional nutrients and a common sense approach to regular exercise, will cleanse the blood, reduce stored toxins and encourage the immune system to rebuild its efficiency.

Author sites: Home Remedies , Herbal Remedies and Natural Skin Care

<a href=”http://www.thefreelibrary.com/Your+Immune+System+and+Allergy-a01073851000″>Your Immune System and Allergy</a>

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by Gabriel Adams

You often don’t think about your Immune System, however as soon as it fails you are quick to realize how vitally important the Immune System is for your overall health. The Immune System is responsible for preventing all bacteria, germs, viruses, and other microorganisms from entering the body and causing complete destruction.

You may not realize it, but the Immune System works 24 hours a day, every day of your life protecting you from all sorts of sickness, disease, and ultimately death. In fact, as soon as any living organism dies, the Immune System immediately stops functioning and the organism is subject to all manner of parasitic invasion. When you stop to think about it, it is truly amazing how the Immune System functions at not only keeping you alive, but also in perfect health.

The Immune System consists of a number of different organs and components. The main components of the Immune System are the Lymph System, The Thymus, Hormones, Bone Marrow, The Spleen, Leukocytes (White Blood Cells), Antibodies, Complement, Tonsils, and Adenoids. Together these components work together to ensure that the Immune System is working in proper order and defends the body against foreign invaders.

In addition to these components, there is another very important organ that is invaluable to ensuring that the Immune System is working and that is the Skin. Skin is often the body’s first line of defense against foreign invaders such as germs, viruses, and bacteria. Therefore, by keeping the skin clean, frequent hand washing, and treating cuts or wounds to prevent infection you can help the Immune System by preventing many invaders from entering the body.

It is a proven fact that stress negatively impacts the Immune System. Therefore, one of the best strategies that you can implement to ensure that your Immune System is operating in its best capacity is to reduce stress. You should also ensure that you receive plenty of sleep every night, and take a vitamin and mineral supplement. Also, there are many herbs that help strengthen the Immune System, adding these to your diet can have a powerful impact on the overall health of your Immune System.

Learn how glyconutritionals can boost immune system function.

Article Source: http://www.articlesnatch.com

http://www.articlesnatch.com/Article/Your-Immune-System–How-It-Works/173250

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