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Immune Systems In Breast Cancer Survivors Who Suffer From Fatigue Fail To Shut Off After Therapy

Aug 23

ScienceDaily (May 1, 2006) — Breast cancer survivors who suffer from persistent, debilitating fatigue years after their diagnosis have something in common: their immune systems don’t shut down following treatment, according to researchers at UCLA’s Jonsson Cancer Center.

This constant immune system activation, which researchers discovered by measuring specific proteins in blood samples from survivors, may be causing the fatigue, UCLA researchers theorize. Their discovery may lead to behavioral interventions such as tai chi and yoga that will help alleviate persistent fatigue, which affects about a third of breast cancer survivors for years after they complete treatment.

The study is the first to look at the cellular basis for immune activation in fatigued breast cancer survivors, said Dr. Michael Irwin, a researcher at UCLA’s Jonsson Cancer Center and the study’s lead author. The research appears in the May 1 issue of Clinical Cancer Research, the peer-reviewed journal of the American Association of Cancer Research.

“Without knowing why this fatigue happens at the cellular level, we can’t develop efficient therapies to treat it,” said Irwin, who also serves as director of the Cousins Center for Psychoneuroimmunology at the Semel Institute for Neuroscience and Human Behavior at UCLA.

“Breast cancer survivors can be severely disabled by fatigue and that can dramatically impact their quality of life. That’s the tragedy of our treatments for cancer,” Irwin said. “We have focused on treating the disease, but we should also focus on the patient’s well being later. Right now, we have no treatment for cancer-related fatigue and we need something that will allow patients to return to their prior level of functioning.”

Dr. Patricia Ganz, a nationally renowned expert who has studied quality of life in breast cancer survivors for two decades, agrees that fatigue is a serious problem for survivors, a fact that their primary care physicians don’t always understand.

“When breast cancer survivors talk to their physicians about being tired and how it affects their lives, they’re often told that they survived cancer, so they should be grateful to be alive,” said Ganz, one of the co-authors of the study. “But their fatigue is a very real problem that needs to taken seriously and addressed.”

A small study at UCLA had previously demonstrated abnormalities in immune activation in breast cancer survivors. If researchers could determine the biological factors underlying this activation, and therefore fatigue, they could uncover a biomarker for the condition that could help them predict which patients would suffer from fatigue and which would not, Irwin said.

Irwin and his colleagues took blood samples from breast cancer survivors one to five years out from diagnosis and placed them into two groups, those who suffered from persistent fatigue and those who did not. The researchers measured the levels of a pro-inflammatory cytokine protein in their blood — levels that indicated the immune system was turned on. Irwin said the pro-inflammatory protein levels were significantly different between the two groups. Those with persistent fatigue had 30 percent more of the proteins circulating in their blood. Additionally, their immune cells produced more cytokines in laboratory analyses than the cells from survivors without fatigue, and those cytokines were more efficient at producing the pro-inflammatory proteins driving the immune response.

“This study proved that there is an aberrant immune response in breast cancer survivors with persistent fatigue,” Irwin said. “With this information, we may now be able to identify those patients at greatest risk for persistent fatigue and implement interventions early on that will lessen the severity and duration of the fatigue.”

The immune systems of women undergoing treatment for breast cancer are activated at high levels to help them fight disease and help the body recover from the side effects of chemotherapy and radiation. Some data suggest that survivors who develop fatigue might have immune system changes before the cancer and the treatments may be exacerbating that. Further studies are needed to understand how this immune activation occurs and what clinical factors predispose to it, Irwin said

“We know from studies that animals with immune activation and cytokines circulating in their blood don’t move around a lot, they don’t eat, they don’t engage in sexual activity,” Irwin said. “From our study, we believe that the severity of fatigue in breast cancer survivors is not related to the type of treatment they received or its duration, but rather that the fatigue is driven by constant immune activation. Their immune systems simply don’t shut down after treatment.”

Irwin and his team studied 32 breast cancer survivors with persistent fatigue and compared their blood samples to 18 survivors who did not suffer from fatigue. The pro-inflammatory proteins in the blood of fatigued cancer survivors could be used as a biomarker to classify those women who may suffer from fatigue after treatment. In those who appear to be predisposed to fatigue — the women whose immune systems have not shut off as they should — it may be possible in the future to provide interventions can right away that might eliminate or, at the least, alleviate the severity and duration of the fatigue.

While there are drugs such as statins that can be used to dampen immune response, future studies by Irwin and his team will focus on behavioral interventions such as tai chi and yoga. Exercise and meditation, Irwin said, have been shown to decrease levels of pro-inflammatory cytokine expression in the blood.

“If we can identify survivors at greatest risk of persistent fatigue, we can implement interventions early on to help them,” Irwin said. “That would be good news for the increasing numbers of women who are surviving breast cancer every year.”

The number of breast cancer survivors is steadily increasing due to advances in screening and treatment strategies. More patients are being diagnosed with early stage breast cancer and are surviving longer. In fact, breast cancer survivors are the largest group of patients to overcome any type of cancer in the United States. It is estimated that there are more than 2 million breast cancer survivors in the U.S. today.

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Walnuts May Prevent Breast Cancer

Jul 31

Walnut consumption may provide the body with essential omega-3 fatty acids, antioxidants and phytosterols that reduce the risk of breast cancer. (Credit: iStockphoto/Elena Elisseeva)

ScienceDaily (Apr. 22, 2009) — Walnut consumption may provide the body with essential omega-3 fatty acids, antioxidants and phytosterols that reduce the risk of breast cancer, according to a study presented at the American Association for Cancer Research 100th Annual Meeting 2009.

Elaine Hardman, Ph.D., associate professor of medicine at Marshall University School of Medicine, said that while her study was done with laboratory animals rather than humans, people should heed the recommendation to eat more walnuts.

“Walnuts are better than cookies, french fries or potato chips when you need a snack,” said Hardman. “We know that a healthy diet overall prevents all manner of chronic diseases.”

Hardman and colleagues studied mice that were fed a diet that they estimated was the human equivalent of two ounces of walnuts per day. A separate group of mice were fed a control diet.

Standard testing showed that walnut consumption significantly decreased breast tumor incidence, the number of glands with a tumor and tumor size.

“These laboratory mice typically have 100 percent tumor incidence at five months; walnut consumption delayed those tumors by at least three weeks,” said Hardman.

Molecular analysis showed that increased consumption of omega-3 fatty acids contributed to the decline in tumor incidence, but other parts of the walnut contributed as well.

“With dietary interventions you see multiple mechanisms when working with the whole food,” said Hardman. “It is clear that walnuts contribute to a healthy diet that can reduce breast cancer.”


Adapted from materials provided by American Association for Cancer Research.

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Boosting Immune ‘Killer Cells,’ Increases Antibody Effectiveness Against Cancer

Jul 24

  • Strengthens immune system
  • Increases and regulates white blood count and red blood cell count – read clinical study
  • Boosts energy
  • Activates NK cells
  • Stimulates macrophages
  • Relieves fatigue
  • __________________________________________________________

Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have devised a novel method to expand the number of immune system “natural killer (NK)” cells from blood cells outside the body. They have found that adding such cells to anti-cancer therapies involving monoclonal antibody drugs is more effective in killing cancer cells, and perhaps someday may improve treatments.

Reporting April 18, 2007 at the annual meeting of the American Association for Cancer Research in Los Angeles, scientists led by Takami Sato, M.D., K. Hasumi Associate Professor of Medical Oncology at Jefferson Medical College of Thomas Jefferson University showed in laboratory studies that adding such NK cells to a monoclonal antibody, Herceptin, which targets the HER2/neu protein on breast cancer cells, was more efficient at killing the cancer cells. The HER2/neu protein is expressed in approximately one-quarter of all breast cancers.

According to Dr. Sato, monoclonal antibodies help kill cancer cells by attaching to the cancer cell surface, in turn stimulating an outpouring of “effector” cells such as NK cells that attempt to neutralize the cancer. NK cells alone are often powerful cancer fighters, he notes, but NK cell function in cancer patients can be diminished, and chemotherapy can make things even worse.

Dr. Sato, international research study coordinator Mizue Terai, M.S., and their co-workers decided to try a different approach. They cultured peripheral blood mononuclear cells, which are a mixture of immune cells, including NK cells, for three weeks in the test tube with their novel technique. The resulting population of NK cells increased 500 to 1,000-fold. In subsequent experiments, they showed that the combination of NK cells and Herceptin was effective in killing HER2/neu-expressing breast cancer cells, though the effect depended on the amount of antibody.

They found that the expanded group of NK cells and antibody had little effect against breast cancer cells that did not express the HER2/neu protein.

“It [the results] doesn’t mean that the antibody and the NK cells will cure the cancer,” Dr. Sato notes, “but it shows that using an antibody that recognizes the cancer cell along with added NK cells can be very effective against the tumor.”

The researchers also found that the monoclonal antibody Rituxan greatly enhanced the cancer cell-killing ability of the expanded NK cells against another cancer cell line, B-cell lymphoma cell line. Rituxan is typically used in combination with chemotherapy to treat patients with B-cell non-Hodgkin’s lymphoma.

Dr. Sato says that the technique can be applied to “any cancer that has a monoclonal antibody available.”

The team’s next step is to test the effectiveness of the added NK cells in an animal model. The group is also in the process of starting an early phase clinical study.

ScienceDaily (Apr. 19, 2007)


Adapted from materials provided by Thomas Jefferson University, via EurekAlert!, a service of AAAS.

Popularity: 3% [?]

Pink-Link: Online Breast Cancer Support Network

Jul 13

Link to a network of fellow survivors,family members, medical pros and others.

Ask questions, share experiences, get information & help each other.

Popularity: 1% [?]

Coping with ‘chemo brain’

Jun 28

Many women who undergo chemotherapy for breast cancer describe unsettling changes to the memory and concentration. Researchers at the University of Michigan Comprehensive Cancer Center say this phenomenon is very real, and have even given it a name: Chemo brain.

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Cancer pain: Relief is possible

Jun 05

Eezapein
Ease Pain Naturally:neck,back, shoulder,arms, hands & fingers, menstrual cramping

Secondary Benefits

  • Non-addictive hot tea
  • Stimulates the body’s natural healing response
  • Calms the mind and body
  • Natural herbal remedies
  • _____________________________________________________________

Cancer pain: Relief is possible

From MayoClinic.com
Special to CNN.com

Not everyone with cancer experiences cancer pain, but one of out three does. If you have advanced cancer — cancer that has spread or recurred — your chance of experiencing cancer pain is even higher.

Cancer pain strikes in many ways. Your pain may be dull, aching or sharp. It could be constant, intermittent, mild, moderate or severe. Timothy Moynihan, M.D., a cancer specialist at Mayo Clinic, Rochester, Minn., offers some insight into cancer pain, reasons why people might not get the pain treatment they need and what they can do about it.

What causes cancer pain?

Cancer pain can result from the cancer itself. Cancer can cause pain by growing into or destroying tissue anywhere near the cancer. Cancer pain can come from the primary cancer itself — where the cancer started — or from other areas in the body where the cancer has spread (metastases). As a tumor grows, it may put pressure on nerves, bones or other organs, causing pain.

Recent research has shown that cancer pain may not just be from the physical effect of the cancer on a region of the body, but also due to chemicals that the cancer may secrete in the region of the tumor. Treatment of the cancer can help the pain in these situations.

Cancer treatments — such as chemotherapy, radiation and surgery — are another potential source of cancer pain. Surgery can be painful, and it may take time to recover. Radiation may leave behind a burning sensation or painful scars. And chemotherapy can cause many potentially painful side effects, including mouth sores, diarrhea and nerve damage.

How do you treat cancer pain?

There are many different ways to treat cancer pain. The ideal way is to remove the source of the pain, for example, through surgery, chemotherapy, radiation or some other form of treatment. If that cannot be done, pain medications can usually control the pain. These medications include:

  • Analgesics, such as aspirin or acetaminophen (Tylenol, others)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin, others)
  • Weak opioid (derived from opium) medications, such as codeine
  • Strong opioid medications, such as morphine, oxycodone, hydromorphone, fentanyl or methadone

These drugs can often be taken orally, so they’re easy to use. However, it you’re unable to take medications orally, they may also be taken intravenously, rectally or through the skin using a patch.

In September 2006 the Food and Drug Administration approved a new form of the opioid fentanyl (Fentora) that dissolves in your mouth. This medication may be particularly effective for intermittent pain episodes, which are sometimes called “incident pain.” These fentanyl tablets dissolve rapidly, and the drug is absorbed through the lining of your mouth.

Specialized treatment, such as nerve blocks, also may be applicable. Nerve blocks are a local anesthetic that is injected around or into a nerve, which prevents pain messages traveling along that nerve pathway from reaching the brain. Other therapies, such as acupuncture, acupressure, massage, physical therapy, relaxation, meditation and humor, may help.

In your experience, what are some reasons for not receiving adequate treatment for cancer pain?

Unfortunately cancer pain is often undertreated. There are many factors behind that, some of which include:

  • Physician knowledge. One factor has to do with a physician’s knowledge and ability to treat and recognize pain. Some physicians and other health care professionals may not specifically ask about pain, which should be a normal part of every cancer patient’s visit. Cancer patients should be asked if they are having any pain. If they are, the physician should stop there and deal with the issue. Some doctors don’t know enough about proper pain treatment. If this is the case, your doctor might refer you to a pain specialist.
  • Patient reluctance. A second factor might be a patient’s own reluctance. Some people might not want to “bother” their doctors with the information, or they may fear that the pain means that their cancer is getting worse. Some are reluctant to report it or report it as thoroughly as they should because they’re worried about what doctors or other people might think of them if they complain. They might feel that because they have cancer, they’re supposed to have pain and be able to deal with it. That simply isn’t true.
  • Fear of addiction. Another factor might be a person’s fear of becoming addicted to the pain medications. This is something that we know doesn’t typically happen if you take medications for pain. If you take them when you’re not in pain or to get high, then, yes, you can get addicted. But the risk of addiction for people who take pain medications in an appropriate fashion — for pain — is very low, so this shouldn’t be a concern.
  • Fear of side effects. Some people fear the side effects of pain medications. Many are afraid of being sleepy, unable to communicate with family and friends, acting strangely, or being seen as dependent on medications. People are also sometimes afraid that taking morphine may shorten their life. There is no evidence of any of these happening if the medication is dosed appropriately. And although strong pain medications can cause drowsiness when you first take them, that side effect usually goes away with steady dosing.

What side effects can you expect from cancer pain treatment, and what can you do about them?

Each pain treatment may be accompanied by its own unique side effects. For example, radiation treatments may cause redness and a burning sensation of the skin. And, depending on what part of the body the radiation is applied to, the radiation may cause diarrhea, mouth sores or other problems, such as fatigue. Chemotherapy certainly can cause side effects, such as nausea, fatigue, infection and hair loss, but it can be effective in relieving pain if it shrinks the tumor. There are medications to help with nausea. Relaxation techniques also may help.

Pain medications each have their own unique side effects that should be reviewed with your physician before taking them. One of the common side effects of the stronger pain medicines is constipation — common to opioids. It can be treated with appropriate bowel regimens as prescribed by your doctor, such as adding a stool softener and something to stimulate the bowels. Preventing constipation is much easier than treating it, so anyone who takes these strong pain medications should automatically begin a regimen to keep their bowels moving. Some of the other side effects of the strong pain medications include confusion, lethargy and sleepiness. The severity of these effects varies from person to person and commonly occurs with the first several doses. But once a steady amount of the medicine stays in your body, the side effects usually resolve. Hallucinations and behavior changes are uncommon.

The less potent pain medications actually may have more side effects, which also should be discussed with your physician before taking them. For instance, anti-inflammatory drugs might damage your kidneys, cause ulcers or increase your blood pressure. Aspirin can cause gastrointestinal bleeding, and acetaminophen (Tylenol, others) can cause liver damage if you take too much.

When should you discuss cancer pain with your doctor, and what points should you bring up?

Report any bothersome pain to your physician. If there is a minor pain that goes away, don’t worry about it. But if the pain interferes with your life or is persistent, it needs to be reported and should be treated. Although no one can guarantee that all pain can be completely eliminated, most pain can be lessened to the point where you can be comfortable.

It may help to keep track of your pain by noting how strong it is, where it’s located, what makes it worse, what brings it on, what makes it better and anything else that happens when you have the pain. A pain-rating scale from 0 to 10 — with 0 being no pain and 10 being the worst pain you can imagine — may be helpful in reporting pain to your doctor. In addition, pay attention to what happens when you attempt to relieve your pain. If you take medicine, do you feel any ill effects from it? If it’s a massage or something physical that relieves the pain, those therapies are important to report, too. Note whether they cause any ill effects.

What steps can you take to make sure you’re receiving adequate cancer pain treatment?

First, you need to talk to your doctor or health care provider if you’re having pain. Second, you and your doctor should set a goal for pain management and monitor the success of the treatment against that goal. Your doctor should track the pain with a pain scale, assessing how strong it is. The goal should be to keep the pain at a level with which you’re comfortable. If you aren’t achieving that goal, talk to your physician. If you’re not getting the answers you need, request a referral to a facility more skilled in the care of pain, particularly a major cancer center. All major cancer centers have pain management programs. For the most part, the medications and treatment for pain are covered by standard insurance.

Popularity: 4% [?]

Healing Herbs for Preventing and Curing Cancer

Mar 09

leucozepin

Leucozepin bestseller
Strengthen Immune System: contains Astragalus

Secondary Benefits

  • Regulates blood cell counts
  • Boosts energy
  • Activates NK cells
  • Stimulates macrophages
  • Relieves fatigue

_____________________________

Healing Herbs for Preventing and Curing Cancer

Dina Hunter

Healing Herbs for Preventing and Curing Cancer No one knows exactly what causes cancer. Research has learned that when the immune system slows down or cannot work properly, cancer and other immune failure diseases seem to take over. The white blood cells are a main part of the immune system. When the white blood cells die or in some way become impaired, the immune system breaks down. Conventional cancer treatments usually consist of surgery, chemotherapy and radiation therapy. These can all lower your white blood cell count and wreak havoc with your immune system. White blood cells are very tough little guys, swimming through our veins, attacking infections and various other “bad germs” in our blood. But they are vulnerable to certain things. They can not do their job well when there is infection. They are killed off by chemotherapy, radiation, mold, chlorine and fluoride in our water supply and metal toxins such as mercury, iron or aluminum. What’s even more frightening is antibiotics, as well as, some pharmaceutical drugs that we are given to help combat disease and infection can sometimes destroy the white blood cells. Many times the very drugs and treatments that kill cancer end up killing the patient because their organs break down and fail to function. So there goes our immune system. In 2002 I was diagnosed with breast cancer. I endured surgery and chemotherapy, which made me horribly sick and left me so weak I could barely walk across the room. When I told the oncologist I was sick and vomiting for several days after each chemo session, she told me it couldn’t be the chemo making me sick. It had to be something else making me vomit. Even after the chemo sessions were over, I was still too weak to do much of anything. I asked the oncologist if there were any herbs or certain kinds of foods I should eat. She said, “No, just eat what you normally eat.” She obviously had no knowledge of herbs or nutrition. So, it looks to me like, if you’re suffering from the effects of chemotherapy or radiation, you’re pretty much on your own. It’s very hard to cope with these vague feelings of tiredness, no energy, depression, irritability, loss of appetite, memory loss and concentration. Most doctors seem to feel these symptoms are unimportant and dismiss them without much thought. One thing we can do is take advantage of the many cancer fighting, immune enhancing herbs, some of which have been around for 1000s of years. Scientists around the world are concentrating on herbal medicines to boost the immune cells of the body in it’s fight against cancer. Find a good herbalist or Doctor of alternative medicine. He or she can put together an herbal formulation based on your body, it’s needs and your life style. Because there are many kinds of cancer and different herbs work in different ways, they are usually not given singly. They work much better in synergistic combinations. Some herbs fight disease by enhancing the immune system. Others work with the lymph system to neutralize toxins and encourage drainage of fluids which flush toxins out of the body. Water, although not an herb, does a very good job of flushing toxins from the body. Just make sure the toxic chemicals that are added to most water systems are filtered out before you drink it. According to the Department of Agriculture there are over 3000 herbs that contain anti-cancer properties. Following is a list of the more common herbs for treating this dreaded disease. Astragalus has been used for more than 5000 years in China. It enhances the immune cells and the natural killer cells that are known to destroy cancer cells. It has been shown in research to speed recovery from chemotherapy and radiation treatments and prolong life expectancy. Astragalus is rarely given alone. According to Chinese medicine it works best when given along with other immune enhancing herbs. Some studies do show that it is effective when used alone and it is certainly worth using. Flaxseed supplements help balance the hormonal system and enhances the immune system and is recommended as a preventative for women who are concerned about breast cancer. Doctors in Germany have been using yarrow along with surgery, radiation and chemotherapy. Garlic and onion has been shown to reduce the risk of cancer of the colon, esophagus and the stomach. Hippocrates was the first to recommend it’s use. Antioxidants are found in most fruits, vegetables and herbs and are known to fight cancer and other diseases. Pau D Arco has been known to shrink cancerous tumors. Burdock, Cat’s Claw, sweet potatoes and pineapple, all have cancer fighting qualities which can detoxify your body and boost the immune system. If you don’t have an herbalist or doctor who will prescribe a synergistic herbal combination to fight cancer for you try eating a wide variety of herbs known to fight cancer and rejuvenate the immune system. Find more information about combating disease with herbs at www.healthyherbalplants.com .

Article Source: http://www.articlesbase.com/cancer-articles/healing-herbs-for-preventing-and-curing-cancer-482749.html

About the Author:

Dina Hunter is the author and owner of www.healthyherbalplants.com She is a firm believer in natural healing with fresh natural foods and herbs.She uses herbs for pain, stress and joint care As a cancer survivor she has done a lot of research on herbs to help This article discusses relevant herbs for preventing and curing cancer and helping the body cope with radiation and chemotherapy, recover from the effects of chemotherapy and radiation.

http://www.articlesbase.com/cancer-articles/healing-herbs-for-preventing-and-curing-cancer-482749.html

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Researchers Find Possible Cause of “Chemo Brain” in Breast Cancer Patients

Mar 09

Thanks to early diagnosis and chemotherapy, more women survive breast cancer than ever before. However, following treatment, approximately 25 percent of survivors experience mild to moderate memory, concentration and cognitive problems known as “chemobrain”.

“Several studies have investigated chemotherapy’s cause and effect on memory problems, but until now scientists had no clue what changes in the brain lead to memory loss,” Jame Abraham, M.D., director of the Comprehensive Breast Cancer Program at West Virginia University’s Mary Babb Randolph Cancer Center, said.

Abraham and his research team conducted one of the first chemobrain studies of its kind. The study documented the extent of changes to the brain’s white matter in women who received chemotherapy for breast cancer.

The preliminary study involved ten breast cancer patients who had received chemotherapy and complained of cognitive changes. A control group of nine healthy women of similar age, education and IQ, who never received chemotherapy, was also studied.

All participants were screened for medical, neurologic and psychiatric conditions that could affect brain structure or function. Participants were tested for depression, anxiety and processing speed.

Each participant also participated in a diffusion tensor imaging (DTI) MRI scan. The DTI was used to assess changes in the white matter of the brain.

“The images indicated differences in the white matter in the front part of the brain in women who had received chemotherapy,” said Marc Haut, Ph.D., of WVU’s departments of Behavioral Medicine and Psychiatry, Neurology and Radiology. “This difference in white matter correlated with how quickly the breast cancer patients could process information.”

“Women who received chemotherapy performed significantly worse in speed of processing than their counterparts in the control group,” said Abraham. “Our preliminary findings suggest that chemotherapy may change the brain and those changes affect the patient’s cognitive skills.”

Morgantown resident Sharon Palmatory, a patient of Dr. Abraham, recently finished chemotherapy treatments. She had very few side effects during chemotherapy, but after treatment experienced trouble remembering names and numbers.

“I can’t multi-task anymore; I can only focus on one thing at a time. It’s frustrating because I am used to being in control,” Palmatory said.

In some patients chemobrain can have a significant and serious affect on their everyday life.

“I feel like I’m always lagging behind in processing information,” she said. “It’s good to know that Dr. Abraham and others are studying this problem; they can let women receiving chemo know that they may experience memory loss.”

WVU researchers also concluded that changes in the white matter of the brain do not appear to be caused by depression or anxiety.

Abraham and Haut are leading several chemobrain studies funded by the U.S. Department of Defense and the WVU Department of Radiology. Their article is published in Clinical Breast Cancer, Volume 8, Number 1, February 2008.

WVU co-authors include Maria Moran, Ph.D., Department of Behavioral Medicine and Psychiatry and Department of Radiology; Shannon Filburn, Clinical Trials Research Unit; and Susan Lemiuex, Center for Advanced Imaging and Department of Radiology. Hiroto Kuwabara, Ph.D., Department of Radiology at Johns Hopkins University, is also a co-author.

Popularity: 1% [?]

Acupuncture reduces side effects of breast cancer treatment as much as conventional drug therapy

Feb 23

Acupuncture is as effective and longer-lasting in managing the common debilitating side effects of hot flashes, night sweats, and excessive sweating (vasomotor symptoms) associated with breast cancer treatment and has no treatment side effects compared to conventional drug therapy, according to a first-of-its-kind study presented September 24, 2008, at the American Society for Therapeutic Radiology and Oncology’s 50th Annual Meeting in Boston. Findings also show there were additional benefits to acupuncture treatment for breast cancer patients, such as an increased sense of well being, more energy, and in some cases, a higher sex drive, that were not experienced in those patients who underwent drug treatment for their hot flashes.

“Our study shows that physicians and patients have an additional therapy for something that affects the majority of breast cancer survivors and actually has benefits, as opposed to more side effects. The effect is more durable than a drug commonly used to treat these vasomotor symptoms and, ultimately, is more cost-effective for insurance companies,” Eleanor Walker, M.D., lead author of the study and a radiation oncologist at the Henry Ford Hospital Department of Radiation Oncology in Detroit, said.

The reduction in hot flashes lasted longer for those breast cancer patients after completing their acupuncture treatment, compared to patients after stopping their drug therapy plan.

Eighty percent of women treated for breast cancer suffer from hot flashes after being treated with chemotherapy and/or anti-estrogen hormones, such as Tamoxifen and Arimidex. Although hormone replacement therapy is typically used to relieve these symptoms, breast cancer patients cannot use this therapy because it may increase the risk of the cancer coming back. As a treatment alternative, patients are generally treated with steroids and/or antidepressant drugs. These drugs, however, have additional side effects, such as weight gain, nausea, constipation and fatigue. The antidepressant, venlafaxine (Effexor), a selective serotonin reuptake inhibitor, is one of the most common drugs used to treat these hot flashes. However, many women decide against this treatment choice because of potential side effects, including decreased libido, insomnia, dizziness and nausea, or because they simply do not want to take any more medications.

The randomized clinical trial compared acupuncture treatment to venlafixine for 12 weeks to find out if acupuncture reduced vasomotor symptoms in breast cancer patients receiving hormonal therapy and produced fewer side effects than venlafaxine. The study involved 47 breast cancer patients who received either Tamoxifen or Arimidex and had at least 14 hot flashes per week. Results show that acupuncture reduces hot flashes as effectively as venlafaxine, with no side effects, and also provides additional health benefits to patients.

Source: American Society for Therapeutic Radiology and Oncology

Popularity: 1% [?]

Side Effects of Chemotherapy

Jan 15

leucozepin

Leucozepin bestseller
Strengthen Immune System: contains Astragalus

Secondary Benefits

  • Regulates blood cell counts
  • Boosts energy
  • Activates NK cells
  • Stimulates macrophages
  • Relieves fatigue
You can imagine a situation where apart from the anguish of having cancer, patients receiving chemotherapy for it find that they also have to deal with the side effects of the treatment which can be fairly devastating.Fortunately like most things in life, understanding the side effects and the causes for it is an excellent place to start in alleviating the suffering. And understanding the basic reason for the side effects of chemotherapy is not as difficult as most people think it is. All you need to grasp is what chemotherapy does to the body. The whole idea behind chemotherapy is to kill cancer cells. However in the course of destroying the deadly cancerous cells the treatment also damages other normal cells. The unavoidable harming of these normal cells is what causes the side effects associated with chemotherapy.

The cells that are usually affected include bone marrow blood cells, cells of hair follicles, cells lining the digestive tract and cells lining the reproductive tract. Looking at this list of the cells that are usually destroyed, one can start to recognize some the ailments that cause so much suffering to people going through chemotherapy treatment. Now you understand exactly why people end up losing their hair for instance. This is as a result of the cells of hair follicles being damaged by chemotherapy.

Bone marrow cells being affected during cancer treatment is one of the most common causes of many of the side effects of chemotherapy. Bone marrow is a thick liquid in the inner part of some bones which usually produces white blood cells. This damage leads to low white blood cell counts or what doctors call neutrophil. The kind of signs and symptoms that follow include fever, sore throat, coughs, shortness of breath, nasal congestion, burning during urination, shaking chills as well as redness, swelling, pain, and warmth at the site of an injury amongst other symptoms.

Usually because of the high risk of infections, doctors may need to delay further chemotherapy doses. These are some of the factors that cause so much suffering amongst cancer patients.

Fortunately new research and clinical trials offers some hope in greatly alleviating problems related to cancer and cancer treatment. For example natural herbal medicines have been used for hundreds of years and now regularly complement mainstream care in managing symptoms, boosting the immune system and greatly enhancing the quality of life. Actually many cancer patients going through chemotherapy have reported impressive results from natural herbal medicine in addressing the side effects of chemotherapy.

Get more information on the Side Effects Of Chemotherapy

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