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Posts in ‘mental health’

Loss Of Sleep, Even For A Single Night, Increases Inflammation In The Body

Sep 26

ScienceDaily (Sep. 4, 2008) — Loss of sleep, even for a few short hours during the night, can prompt one’s immune system to turn against healthy tissue and organs.

A new article in the September 15th issue of Biological Psychiatry, by the UCLA Cousins Center research team, reports that losing sleep for even part of one night can trigger the key cellular pathway that produces tissue-damaging inflammation. The findings suggest a good night’s sleep can ease the risk of both heart disease and autoimmune disorders such as rheumatoid arthritis.

Specifically, the researchers measured the levels of nuclear factor (NF)-?B, a transcription factor that serves a vital role in the body’s inflammatory signaling, in healthy adults. These measurements were repeatedly assessed, including in the morning after baseline (or normal) sleep, after partial sleep deprivation (where the volunteers were awake from 11 pm to 3:00 am), and after recovery sleep. In the morning after sleep loss, they discovered that activation of (NF)-?B signaling was significantly greater than after baseline or recovery sleep. It’s important to note that they found this increase in inflammatory response in only the female subjects.

These data close an important gap in understanding the cellular mechanisms by which sleep loss enhances inflammatory biology in humans, with implications for understanding the association between sleep disturbance and risk of a wide spectrum of medical conditions including cardiovascular disease, arthritis, diabetes, certain cancers, and obesity. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: “The closer that we look at sleep, the more that we learn about the benefits of sleeping. In this case, Irwin and colleagues provide evidence that sleep deprivation is associated with enhancement of pro-inflammatory processes in the body.”

“Physical and psychological stress brought on in part by grinding work, school and social schedules is keeping millions of Americans up at night,” said Dr. Irwin, lead author and director of the Cousins Center for Psychoneuroimmunology at the Semel Institute. “America’s sleep habits are simply not healthy. Our findings suggest even modest sleep loss may play a role in common disorders that affect sweeping segments of the population.” In other words, sleep is vitally important to maintaining a healthy body. And as Dr. Krystal notes, “these findings provide a potential mechanistic avenue through which addressing sleep disturbance might improve health.”

Cancer and loss of libido: How treatment affects desire

Sep 26

From MayoClinic.com
Special to CNN.com

Whether it’s cuddling, kissing or sex, intimacy with a loving partner can help you feel better about yourself as you go through cancer treatment. During and after your treatment, you may find that your libido has changed. Loss of libido is the most common problem affecting cancer survivors looking to continue or resume sexual intimacy.

Losing interest in sexual activity can create tension between you and your partner, adding to the stress of treatment. Identifying the causes of your disinterest is the first step toward finding a solution. Open communication with your partner and your doctor can help you regain your libido or help you redefine what it means to be intimate.

Physical changes that can cause loss of libido

Loss of libido may be caused by physical changes to your body as a result of cancer treatment. For instance, women may experience symptoms of early menopause, such as vaginal dryness, and men may experience erectile dysfunction. Discuss these changes with your doctor.

Feelings that can cause loss of libido

Cancer is a physical disease, but going through a cancer diagnosis and treatment can be very emotional. You may worry about your future, stress over your treatment decisions and find joy in the small triumphs in overcoming your cancer. All of these emotions influence how you feel about yourself and your attitude toward intimacy. Some common feelings that can negatively affect your libido include:

Guilt
You may feel guilty because you feel previous sexual experiences caused your cancer. Cancer can’t be transmitted sexually. Although some cancers are more likely in people who have human papillomavirus (HPV), which is transmitted sexually, many people live with HPV and never develop cancer. Other sexually transmitted viruses that put you at risk of cancer include hepatitis C, HIV and Epstein-Barr virus.

Fear
You may fear that sexual activity can cause a recurrence of your cancer or that you will pass your cancer on to your partner. Sexual activity has no influence on whether you’ll experience a cancer recurrence. Your doctor can discuss your prognosis and chances for a cancer-free life. You can’t pass your cancer on to another person.

Depression
Sadness or feelings of worthlessness are common signs of depression, which causes a loss of libido and decreases the pleasure you experience during sex. People with cancer are more likely than others to experience depression. Depression is treatable, so talk to your doctor about your feelings.

Self-consciousness
Changes to your appearance after cancer treatment can make you feel self-conscious. For instance, the loss of your hair from chemotherapy, the loss of a limb, breast, or testicle, scars from surgery, and ostomies can make you feel less attractive. Many people find that their partners aren’t as concerned about these changes as they are. Still, it takes time to become comfortable with the changes in your appearance. Your doctor may have suggestions to help you regain your self-confidence. Talk with other cancer survivors for ideas on ways to make you feel more sexually attractive.

Grief and loss
Feelings of grief and loss can result if you feel cancer treatment has significantly changed your body. Some people might say they feel less feminine or masculine. For instance, a woman who has a hysterectomy may feel a sense of loss and perceive herself as less of a woman. A man may feel he’s less of a man if he has his testicles removed (orchiectomy). For some people, treatments alter how they view themselves and make them very dissatisfied with their bodies. Although some sense of grief and loss is expected with the physical changes, you can and should feel satisfied with your body and feel positive about yourself. Talk to your doctor about how you feel. Ask him or her for a referral to a clinical health psychologist if you have strong feelings of dissatisfaction with yourself and your body.

Stress
Being diagnosed with cancer and beginning your treatment is stressful. This makes it difficult to get into an intimate mood because your mind is distracted. If you’re in a relationship, stress can exacerbate any pre-existing problems you may have had. Talk with your partner about how you feel.

Anxiety
The thought of resuming sex after your cancer can cause anxiety. You might be unsure of how you’ll perform. If you have a partner, you might find yourself avoiding all intimacy. If you’re single, you might be hesitant to date because you aren’t sure how or when you’ll reveal your cancer experience to a new partner. Anxiety is common, and it may help to talk through your feelings with your partner, your doctor or a clinical health psychologist.

Consider your partner’s feelings toward sex

Many times, cancer survivors say their partners go through cancer with them — standing by them and supporting them from the first diagnosis through the uncertainty of life after treatment. It’s an emotional time for your partner, too, and sometimes partners feel afraid or reluctant to resume sex. Your partner may be afraid that he or she will hurt you or that you’ll interpret his or her advances as pressure to have sex. Your partner’s role as caregiver during your treatment can make him or her see you as a vulnerable patient, rather than the partner you think of yourself as.

In many cases, communication about how both of you feel can make situations like these easier. But many couples didn’t spend much time discussing sex before, and adding cancer to the mix makes it all the more difficult. Couples therapy may help you open the lines of communication and better understand your situation.

What you can do to regain your libido

If you’ve experienced a loss of libido, you may feel alone. You might not want to talk about your feelings, but you should. The problem won’t resolve on its own. It will take cooperation between you, your partner and your health care team to ensure that you feel comfortable resuming sexual activity. Consider trying to:

  • Talk with your doctor or nurse. If your doctor hasn’t discussed sexuality, take the lead. Your doctor or nurse can help you find resources and refer you to a clinical health psychologist.
  • Talk with your partner. One of the best ways to improve libido is to open the lines of communication between you and your partner. For instance, your partner may fear hurting you during sex and may avoid initiating sexual activity. You may believe your partner is no longer interested in you. A conversation about the issue can clear the air and restore emotional and physical intimacy.
  • Talk with other cancer survivors. People who have had your same cancer and have endured your same treatment are likely experiencing the same loss of libido. Look for other cancer survivors in support groups in your area, or you may be more comfortable connecting with other survivors on Internet message boards. Contact the American Cancer Society for information.
  • Change your definition of sexual intimacy. Maybe you aren’t ready for sex. Talk about this with your partner and look for other ways you can be intimate. Simply spending quality time together may help you reconnect and slowly move toward resuming sexual intimacy.
  • Track your desire. You might think you’ve lost all interest in sex, but you may have sexual thoughts throughout your day that you ignore. Make a note of times during the day when you think about sex. If you find certain times of the day or certain situations rouse your interest in sex, use those cues to help put you in the mood.

Loss of libido is common after cancer treatment, but that doesn’t mean you can’t regain the sexual intimacy you once enjoyed. Broaching the subject with your doctor, partner or even members of a support group may help you work through your emotions and enable you to resume a satisfying sexual relationship.

Do Antidepressants Enhance Immune Function?

May 12

ScienceDaily (May 9, 2008) — Infection with human immunodeficiency virus (HIV), which leads to acquired immunodeficiency syndrome (AIDS), is an epidemic of global concern. According to the most recent estimates, released in November 2007, by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO), an estimated 33.2 million worldwide are living with HIV infection currently. Although the rates of infection appear to be decreasing, there are obviously immense implications for achieving improvements in HIV/AIDS treatment.

The functioning of natural killer (NK) cells, which are a major element of the innate immunity system and are involved in the body’s first line of defense against infections such as HIV, is decreased in both HIV and depression. A group of researchers who have previously found that stress and depression impair NK cell function and accelerate the course of HIV/AIDS are now publishing a new report in Biological Psychiatry.

In this study, they recruited both depressed and non-depressed HIV-infected women and studied the ex vivo effects of three drugs, a selective serotonin reuptake inhibitor (SSRI), a substance P antagonist, and a glucocorticoid antagonist, on their NK cell activity. These drugs were selected because, as the authors state, each “affect[s] underlying regulatory systems that have been extensively investigated in both stress and depression research as well as immune and viral research.”

The scientists found that the SSRI citalopram, and the substance P antagonist CP 96,345, but not the glucocorticoid receptor antagonist RU486, increased NK cell activity. According to Dr. Dwight Evans, corresponding author of the article: “The present findings provide evidence that natural killer cell function in HIV infection may be enhanced by selective serotonin reuptake inhibition and also by substance P antagonism in both depressed and non-depressed individuals.”

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: “There has been growing evidence that the compromise of immune function associated with depression influences the outcomes of infectious diseases and cancer. Antidepressant treatments are beginning to be studied for their potential positive effects on immune function.”

He adds that “the paper by Evans et al. suggests that antidepressant treatment may have positive effects on natural killer cell activity in cells isolated from individuals infected with HIV with and without depression. This type of bridge between the brain and the rest of the body deserves further attention.” Dr. Evans agrees, noting that “these findings begin to pave the way towards initiating clinical studies addressing the potential role of serotonergic agents and substance P antagonists in improving natural killer cell innate immunity, possibly delaying HIV disease progression and extending survival with HIV infection.”


Journal reference:

  1. Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. Dwight L. Evans, Kevin G. Lynch, Tami Benton, Benoit Dubé, David R. Gettes, Nancy B. Tustin, Jian Ping Lai, David Metzger and Steven D. Douglas. Drs. Evans, Lynch, Benton, Dubé, and Metzger and Mr. Gettes are affiliated with the Department of Psychiatry, with Dr. Evans also with the Departments of Medicine and Neuroscience, and Dr. Douglas is with the Department of Pediatrics, all at the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania. Ms. Tustin and Drs. Lai and Douglas are with the Division of Allergy and Immunology, Joseph J. Stokes Research Institute of The Children’s Hospital of Philadelphia, in Philadelphia, Pennsylvania. Biological Psychiatry, Volume 63, Issue 9 (May 1, 2008).

Adapted from materials provided by Elsevier, via EurekAlert!, a service of AAAS.