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Posts from September, 2007

Cancer Prevalence: How Many People Have Cancer?

Sep 02

Cancer prevalence is defined as the total number of people living with cancer at any point in time. It includes both people diagnosed with cancer in the past (who are still alive) as well as people recently diagnosed.

Cancer prevalence is not a measure of how common a cancer is. This number is reflected by cancer incidence, which is the number of people newly diagnosed with cancer in a given time period (usually one year). Prevalence is affected both by the incidence of a cancer and by how long people normally live with the disease.

For example, lung cancer is the second most common cancer in both men and women, but lung cancer prevalence is not as high as that of some less common cancers because people with lung cancer tend not to live as long once diagnosed.

The following numbers come from the US National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) database for the year 2002, the most recent year for which reliable estimates are available. These are estimates based on a sampling of the US population. Numbers may not add up due to rounding to the nearest 1,000.

Estimated United States Cancer Prevalence, 2002
  Total Males Females
All Sites

10,146,000

4,504,000

5,642,000

Brain & Other Nervous System

106,000

57,000

49,000

Breast

2,290,000

12,000

2,278,000

Cervix

223,000

0

223,000

Colon & Rectum

1,052,000

505,000

546,000

Endometrial Cancerand Uterine Sarcoma

572,000

0

572,000

Esophagus

23,000

18,000

6,000

Hodgkin Disease

146,000

76,000

69,000

Kidney & Renal Pelvis

221,000

131,000

91,000

Larynx

98,000

78,000

20,000

Leukemias

189,000

106,000

83,000

Liver & Bile Duct

16,000

9,000

6,000

Lung & Bronchus

351,000

174,000

176,000

Melanoma of Skin

630,000

304,000

326,000

Multiple Myeloma

50,000

27,000

23,000

Non-Hodgkin Lymphoma

347,000

180,000

167,000

Oral Cavity & Pharynx

232,000

147,000

85,000

Ovary

170,000

0

170,000

Pancreas

26,000

12,000

14,000

Prostate

1,832,000

1,832,000

0

Stomach

59,000

34,000

25,000

Testis

164,000

164,000

0

Thyroid

327,000

75,000

252,000

Urinary Bladder

499,000

368,000

132,000

Childhood Cancer (0-19 years)

216,000

110,000

105,000

References

National Cancer Institute. SEER Cancer Statistics Review, 1975-2002. 2006.
Available at: http://seer.cancer.gov/csr/1975_2002/
Accessed January 31, 2006.
Revised: 02/22/2006

Most “Abnormal” Pap Smears Won’t Lead to Cancer

Sep 02

LONDON (Reuters Health) - At least 80 percent of women who have worrying evidence of cell abnormalities on a Pap smear will not go on to develop cervical cancer, a new analysis by British researchers suggests.
All of these women will be treated “just in case,” meaning that many will undergo further tests and small operations. But cervical cancer treatments are relatively minor, and not too invasive, meaning Pap screening is still worth doing despite these problems, say Dr. Angela E. Raffle and colleagues.
“You can’t escape the fact that to be effective in cancer screening you almost have to over-treat because the cell changes and tissue changes are so common,” said Raffle, from Avon Health Authority in Bristol.
Her group analyzed screening records from 348,419 women in the Bristol area. They report their findings in Friday’s British Medical Journal.
For every 10,000 women screened between 1976 and 1996, 1,564 had abnormal cervical cells detected in the Pap smear. Of those, 818 had further investigations, of whom 543 had evidence of abnormal cervical tissue. Within this group, 176 had abnormalities that persisted for 2 or more years.
Without screening, the researchers say, 80 of these women would be expected to develop cancer by 2011, of whom 25 would die. Screening would avoid 10 of these deaths.
“In the NHS cervical screening programme, around 1,000 women need to be screened for 35 years to prevent one death,” they write.
An important implication of their results is the need to help women understand what an abnormal Pap smear really means, the researchers say. While it is important for women to have tests and not to ignore the results, trauma caused by thinking it is something akin to a death sentence is not necessary.
“We really need to change people’s perception of what’s meant by an abnormal smear,” Raffle said.
“Most of these abnormalities are no problem at all, but the treatment’s simple and we really think that everyone with a high grade abnormality needs treatment because we know that for one in eighty it will make that big, life-saving difference.”
Cervical cancer is ideal for screening, because doctors can get to the cervix without surgery, it can be treated locally, Raffle said. But the same cannot be said of all other cancers.
“I think the real implications for our findings are for prostate cancer, bowel cancer, ovarian cancer — all these others that people say we must start screening for,” the Bristol researcher said.
It is possible that a large proportion of abnormalities detected in those organs will never develop into cancer, but the treatment can be much more damaging than that for cervical cancer — involving major surgery or radiation treatment.
“Our study points to the potential for harm. It’s only minimal harm with the cervix because you’re talking about worrying people, but if you’re talking about an operation that could leave you dead, or impotent or incontinent, then it’s a different equation really,” Raffle said.

Complementary Therapies Help Cancer Patients

Sep 02

A new Perth study has found alternative therapies like acupuncture and massage significantly improve the well- being of cancer patients.

More than 500 patients in the study began using complementary treatments in addition to traditional medicine like chemotherapy and morphine over a 17-month period.
The researchers at Sir Charles Gairdner Hospital found the therapies relieved physical symptoms such as nausea and pain, while improving the patient’s overall quality of life.

The director of the Cancer Support Centre, David Joske, says the treatments worked extremely well but more research needs to be done “to start to ask how can we get the best out of these two worlds which in the past really have been mutually exclusive in our society”.

He says he hopes the study gives greater credibility to the benefits of complementary medicine.